Y prif ddulliau cynhyrchu ovalineyn eplesu biolegol, ensymatig, synthesis cemegol ac echdynnu hydrolysis protein.
Gall Valine gael ei gynhyrchu gan synthesis cemegol, ond nodweddir synthesis cemegol gan gost cynhyrchu uchel, adwaith cymhleth, llawer o gamau, a llawer o sgil-gynhyrchion. Mae eplesu biolegol yn disodli echdynnu uniongyrchol a synthesis cemegol fel y prif ddull ar gyfer cynhyrchu L-valine.
Cynhyrchu Valine Mewn Burum
Microbial fermentation has the advantages of low cost of raw materials, high yeast yield and large-scale production. It can overcome the shortcomings of enzymatic, chemical synthesis and proteolytic extraction. This is a very economical production method. The valine produced by the fermentation method is all L-type, and does not need to be resolved by optical rotation. The strains of the fermentation method are Micrococcus glutamicum, Brevibacterium ammoniagenes, Escherichia coli, and Aerobacter aerogenes. Use glucose, urea, inorganic salts and other media. Generally, it can be produced quickly, and don't worry too much about insufficient output.
Ar y llaw arall, gydag iteriad parhaus ac optimeiddio biotechnoleg, mae datblygiadau sylweddol wedi'u gwneud yn nhechnoleg eplesu biolegol valine. Mae gan y straen cynhyrchu nid yn unig gapasiti cynhyrchu L-valine uwch, ond hefyd llai o groniad o sgil-gynhyrchion. Ar ben hynny, gellir symleiddio'r broses wahanu a phuro dilynol hefyd, gan leihau costau cynhyrchu.
Mae maint a galw'r farchnad L valine fyd-eang wedi gordyfu yn y blynyddoedd diwethaf. Cyfradd tyfiant blynyddol cyfansawdd valine gradd porthiant o 2015 i 2020 yw 48 y cant . Felly, gyda eplesu biolegol fel y brif ffrwd,valinegellir ei gynhyrchu ar raddfa fawr ac am gost isel i gwrdd â mwy o ofynion.